New type of biodegradable porous scaffolds for tissue-engineered articular cartilage

Makoto Kawanishi; Takashi Ushida; Tadashi Kaneko; Hideo Niwa; Toru Fukubayashi; Kozo Nakamura; Hiromi Oda; Sakae Tanaka; Tetsuya Tateishi

doi:10.1016/j.msec.2003.11.008

New type of biodegradable porous scaffolds for tissue-engineered articular cartilage

Makoto Kawanishi^*, Takashi Ushida, Tadashi Kaneko, Hideo Niwa, Toru Fukubayashi, Kozo Nakamura, Hiromi Oda, Sakae Tanaka, Tetsuya Tateishi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. The pore structures had two layers, a leaching side (upper) and a freeze-drying side (lower). The latter had columnar pores to simulate a radial zone, while the leaching side simulated the tangential zone of the articular cartilage. In this study, we showed that this structure enabled the uniform seeding of goat chondrocytes in the scaffolds, and with low rates of leakage.

Original language	English
Pages (from-to)	431-435
Number of pages	5
Journal	Materials Science and Engineering C
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/j.msec.2003.11.008
Publication status	Published - 2004 Apr 1
Externally published	Yes

Keywords

Articular cartilage
Biodegradable polymer
Tissue engineering

ASJC Scopus subject areas

Biomaterials

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10.1016/j.msec.2003.11.008

Cite this

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abstract = "Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. The pore structures had two layers, a leaching side (upper) and a freeze-drying side (lower). The latter had columnar pores to simulate a radial zone, while the leaching side simulated the tangential zone of the articular cartilage. In this study, we showed that this structure enabled the uniform seeding of goat chondrocytes in the scaffolds, and with low rates of leakage.",

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AU - Kawanishi, Makoto

AU - Ushida, Takashi

AU - Kaneko, Tadashi

AU - Niwa, Hideo

AU - Fukubayashi, Toru

AU - Nakamura, Kozo

AU - Oda, Hiromi

AU - Tanaka, Sakae

AU - Tateishi, Tetsuya

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AB - Three-dimensional biodegradable porous scaffolds play an important role in tissue engineering. We created double-layered porous scaffolds composed of synthetic biodegradable polymers by combining freeze-drying and porogen leaching techniques to create tissue- engineered articular cartilage. The pore structures had two layers, a leaching side (upper) and a freeze-drying side (lower). The latter had columnar pores to simulate a radial zone, while the leaching side simulated the tangential zone of the articular cartilage. In this study, we showed that this structure enabled the uniform seeding of goat chondrocytes in the scaffolds, and with low rates of leakage.

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New type of biodegradable porous scaffolds for tissue-engineered articular cartilage

Abstract

Keywords

ASJC Scopus subject areas

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