Newly-developed positron emission mammography (PEM) device for the detection of small breast cancer

Ai Yanai; Masatoshi Itoh; Hisashi Hirakawa; Kazuhiko Yanai; Manabu Tashiro; Ryuichi Harada; Akira Yoshikawa; Seiichi Yamamoto; Noriaki Ohuchi; Takanori Ishida

doi:10.1620/tjem.245.13

Newly-developed positron emission mammography (PEM) device for the detection of small breast cancer

Ai Yanai, Masatoshi Itoh, Hisashi Hirakawa, Kazuhiko Yanai^*, Manabu Tashiro, Ryuichi Harada, Akira Yoshikawa, Seiichi Yamamoto, Noriaki Ohuchi, Takanori Ishida

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [¹⁸F]fluoro-2-deoxy-2-fluoro-D-glucose ([¹⁸F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [¹⁸F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [¹⁸F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [¹⁸F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.

Original language	English
Pages (from-to)	13-19
Number of pages	7
Journal	Tohoku Journal of Experimental Medicine
Volume	245
Issue number	1
DOIs	https://doi.org/10.1620/tjem.245.13
Publication status	Published - 2018 May
Externally published	Yes

Keywords

F-FDG
Breast cancer
Histology
PET/CT
Positron emission mammography (PEM)

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1620/tjem.245.13

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@article{b5142f1fcc4446c2a9b13ac2bd5fad91,

title = "Newly-developed positron emission mammography (PEM) device for the detection of small breast cancer",

abstract = "Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [18F]fluoro-2-deoxy-2-fluoro-D-glucose ([18F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [18F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [18F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [18F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.",

keywords = "F-FDG, Breast cancer, Histology, PET/CT, Positron emission mammography (PEM)",

author = "Ai Yanai and Masatoshi Itoh and Hisashi Hirakawa and Kazuhiko Yanai and Manabu Tashiro and Ryuichi Harada and Akira Yoshikawa and Seiichi Yamamoto and Noriaki Ohuchi and Takanori Ishida",

note = "Funding Information: This work was partially supported by a Grant-in-Aid for challenging Exploratory Research (16K15314), Japan Society of Promotion for the Promotion of Science (JSPS). We appreciate Professor Hiroshi Watabe (CYRIC) and Mr. Shoichi Watanuki for discussing the manuscript. The authors also thank Drs. Rie Sugai and Katsuhiko Shibuya for supporting PET/CT and PEM imaging. Publisher Copyright: {\textcopyright} 2018 Tohoku University Medical Press.",

year = "2018",

month = may,

doi = "10.1620/tjem.245.13",

language = "English",

volume = "245",

pages = "13--19",

journal = "Tohoku Journal of Experimental Medicine",

issn = "0040-8727",

publisher = "Tohoku University Medical Press",

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TY - JOUR

T1 - Newly-developed positron emission mammography (PEM) device for the detection of small breast cancer

AU - Yanai, Ai

AU - Itoh, Masatoshi

AU - Hirakawa, Hisashi

AU - Yanai, Kazuhiko

AU - Tashiro, Manabu

AU - Harada, Ryuichi

AU - Yoshikawa, Akira

AU - Yamamoto, Seiichi

AU - Ohuchi, Noriaki

AU - Ishida, Takanori

N1 - Funding Information: This work was partially supported by a Grant-in-Aid for challenging Exploratory Research (16K15314), Japan Society of Promotion for the Promotion of Science (JSPS). We appreciate Professor Hiroshi Watabe (CYRIC) and Mr. Shoichi Watanuki for discussing the manuscript. The authors also thank Drs. Rie Sugai and Katsuhiko Shibuya for supporting PET/CT and PEM imaging. Publisher Copyright: © 2018 Tohoku University Medical Press.

PY - 2018/5

Y1 - 2018/5

N2 - Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [18F]fluoro-2-deoxy-2-fluoro-D-glucose ([18F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [18F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [18F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [18F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.

AB - Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [18F]fluoro-2-deoxy-2-fluoro-D-glucose ([18F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [18F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [18F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [18F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.

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KW - Histology

KW - PET/CT

KW - Positron emission mammography (PEM)

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JF - Tohoku Journal of Experimental Medicine

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ER -

Newly-developed positron emission mammography (PEM) device for the detection of small breast cancer

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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