Ni-Catalyzed α-arylation of esters and amides with phenol derivatives

Eva Koch, Ryosuke Takise, Armido Studer, Junichiro Yamaguchi*, Kenichiro Itami

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


A nickel-catalyzed α-arylation of esters and amides with phenol derivatives has been accomplished. In the presence of our unique nickel catalyst, prepared in situ from Ni(cod)2, 3,4-bis(dicyclohexylphosphino)thiophene (dcypt), and K3PO4, various esters and amides undergo α-arylation with O-arylpivalates or O-arylcarbamates to afford the corresponding coupling products. The thus obtained α-aryl esters and amides are useful precursors of privileged motifs such as α-arylcarboxylic acids and β-arylamines.

Original languageEnglish
Pages (from-to)855-857
Number of pages3
JournalChemical Communications
Issue number5
Publication statusPublished - 2015 Jan 18
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • General Chemistry
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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