Nickel-catalyzed addition of pyridine-N-oxides across alkynes

Kyalo Stephen Kanyiva*, Yoshiaki Nakao, Tamejiro Hiyama

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

254 Citations (Scopus)


(Chemical Equation Presented) An alternative to pyridine: Pyridine-N-oxides undergo direct C-H activation and add across alkynes under mild nickel catalysis to afford (E)-2-alkenylpyridine-N-oxides in modest to good yields with high selectivity. Subsequent deoxygenation and deoxygenative functionalization proceed smoothly to give a wide variety of 2-substituted pyridines. PCyp 3 = tricyclopentylphosphine, cod = cyclooctadiene.

Original languageEnglish
Pages (from-to)8872-8874
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number46
Publication statusPublished - 2007
Externally publishedYes


  • Alkynes
  • C-C coupling
  • C-H activation
  • Nickel
  • Pyridine-N-oxides

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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