Nickel-catalyzed direct coupling of heteroarenes

Junichiro Yamaguchi, Kei Muto, Kazuma Amaike, Takuya Yamamoto, Kenichiro Itami

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Nickel-catalyzed cross-coupling reactions have recently been receiving significant attention from the synthetic community as a way to construct carbon-carbon or carbon-heteroatom bonds, because nickel catalysts are less expensive and less toxic than palladium catalysts. We herein describe our recent developments in nickel-catalyzed biaryl coupling methodology, along with mechanistic studies and applications to the synthesis of natural products and pharmaceuticals. In particular, we focus on nickel-catalyzed direct coupling reactions in which "unreactive" bonds such as C-H, C-O, and C-C bonds are converted into biaryl moieties.

Original languageEnglish
Pages (from-to)576-587
Number of pages12
JournalYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
Issue number6
Publication statusPublished - 2013
Externally publishedYes


  • C-H arylation
  • Cross-coupling
  • Febuxostat
  • Heterobiaryl
  • Muscoride A
  • Nickel
  • Tafamidis
  • Texaline
  • Texamine

ASJC Scopus subject areas

  • Organic Chemistry


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