TY - JOUR
T1 - NiFe-layered double hydroxide sheets as an efficient electrochemical biosensing platform
AU - Nesakumar, Noel
AU - Anantharaj, Sengeni
AU - Subramanian, Nandhini
AU - Kundu, Subrata
AU - Alwarappan, Subbiah
N1 - Funding Information:
Dr N.N thank Science and Engineering Research Board, Department of Science and Technology, Government of India (PDF/2016/001584) for the SERB-National Post Doctoral Fellowship (N-PDF). SA acknowledge CSIR, New Delhi, India for the award of SRF fellowship. Dr SA, N.N and SA thank CIF at CSIR-CECRI for their support during surface characterization.
Publisher Copyright:
© 2018 The Electrochemical Society.
PY - 2018
Y1 - 2018
N2 - The maximum allowed limits of chlorpromazine (CPZ) established by Food and Drug Administration (FDA) for children aged between 1 and 5 years is 0.125 mM and between 6 to 12 years is 0.235 mM. However, excess consumption of CPZ beyond these permissible limit cause adverse health effects. In order to detect CPZ, herein, we employ NiFe-layered double hydroxide sheets modified glassy carbon electrode (GC/NiFe LDH). The GC/NiFe LDH electrode exhibited a good electrocatalytic activity towards CPZ detection at a less working potential even in the presence of interferents such as ascorbic acid, uric acid, glucose, sucrose, fructose and acetaminophen. The anodic peak observed at 614 mV (vs. Ag/AgCl) corresponds to the oxidation of CPZ and the proposed platform exhibited an excellent linearity in the range 75 μM to 1.0 mM. Further, the GC/NiFe LDH electrode exhibited an excellent sensitivity (1.05 μA μM−1), repeatability (0.86% RSD), reproducibility (1.54% RSD) and limit of detection (1.23 μM).
AB - The maximum allowed limits of chlorpromazine (CPZ) established by Food and Drug Administration (FDA) for children aged between 1 and 5 years is 0.125 mM and between 6 to 12 years is 0.235 mM. However, excess consumption of CPZ beyond these permissible limit cause adverse health effects. In order to detect CPZ, herein, we employ NiFe-layered double hydroxide sheets modified glassy carbon electrode (GC/NiFe LDH). The GC/NiFe LDH electrode exhibited a good electrocatalytic activity towards CPZ detection at a less working potential even in the presence of interferents such as ascorbic acid, uric acid, glucose, sucrose, fructose and acetaminophen. The anodic peak observed at 614 mV (vs. Ag/AgCl) corresponds to the oxidation of CPZ and the proposed platform exhibited an excellent linearity in the range 75 μM to 1.0 mM. Further, the GC/NiFe LDH electrode exhibited an excellent sensitivity (1.05 μA μM−1), repeatability (0.86% RSD), reproducibility (1.54% RSD) and limit of detection (1.23 μM).
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U2 - 10.1149/2.1301811jes
DO - 10.1149/2.1301811jes
M3 - Article
AN - SCOPUS:85067391129
SN - 0013-4651
VL - 165
SP - B536-B542
JO - Journal of the Electrochemical Society
JF - Journal of the Electrochemical Society
IS - 11
ER -
