Nitric oxide: Is it the cause of muscle soreness?

Zsolt Radak; Hisashi Naito; Albert W. Taylor; Sataro Goto

doi:10.1016/j.niox.2011.12.005

Nitric oxide: Is it the cause of muscle soreness?

Zsolt Radak^*, Hisashi Naito, Albert W. Taylor, Sataro Goto

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.

Original language	English
Pages (from-to)	89-94
Number of pages	6
Journal	Nitric Oxide - Biology and Chemistry
Volume	26
Issue number	2
DOIs	https://doi.org/10.1016/j.niox.2011.12.005
Publication status	Published - 2012 Feb 15
Externally published	Yes

Keywords

Exercise
Hormesis
Muscle damage
Pain
Skeletal muscle

ASJC Scopus subject areas

Biochemistry
Physiology
Clinical Biochemistry
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.niox.2011.12.005

Cite this

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title = "Nitric oxide: Is it the cause of muscle soreness?",

abstract = "Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.",

keywords = "Exercise, Hormesis, Muscle damage, Pain, Skeletal muscle",

author = "Zsolt Radak and Hisashi Naito and Taylor, {Albert W.} and Sataro Goto",

note = "Funding Information: The present work was supported by Hungarian grants by ETT 38388, OTKA (K75702), T{\'e}T JAP13/02, JSPS (L-10566) awarded to Z. Rad{\'a}k.",

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doi = "10.1016/j.niox.2011.12.005",

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T2 - Is it the cause of muscle soreness?

AU - Radak, Zsolt

AU - Naito, Hisashi

AU - Taylor, Albert W.

AU - Goto, Sataro

N1 - Funding Information: The present work was supported by Hungarian grants by ETT 38388, OTKA (K75702), TéT JAP13/02, JSPS (L-10566) awarded to Z. Radák.

PY - 2012/2/15

Y1 - 2012/2/15

N2 - Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.

AB - Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.

KW - Exercise

KW - Hormesis

KW - Muscle damage

KW - Pain

KW - Skeletal muscle

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Nitric oxide: Is it the cause of muscle soreness?

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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