Nitric oxide: Is it the cause of muscle soreness?

Zsolt Radak*, Hisashi Naito, Albert W. Taylor, Sataro Goto

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)


Skeletal muscle hosts all of the isoforms of nitric oxide synthase (NOS). It is well documented that nitric oxide (NO) regulates force generation and satellite cell activation, and therefore, damage repair of skeletal muscle. NO can also activate nociceptors of C-fibers, thereby causing the sensation of pain. Although delayed-onset of muscle soreness (DOMS) is associated with decreased maximal force generation, pain sensation and sarcomere damage, there is a paucity of research linking NO and DOMS. The present mini-review attempts to elucidate the possible relationship between NO and DOMS, based upon current literature.

Original languageEnglish
Pages (from-to)89-94
Number of pages6
JournalNitric Oxide - Biology and Chemistry
Issue number2
Publication statusPublished - 2012 Feb 15
Externally publishedYes


  • Exercise
  • Hormesis
  • Muscle damage
  • Pain
  • Skeletal muscle

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cancer Research


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