TY - JOUR
T1 - NMDA induced glutamate release from the suprachiasmatic nucleus
T2 - An in vitro study in the rat
AU - Hamada, Toshiyuki
AU - Sonoda, Rie
AU - Watanabe, Akihito
AU - Ono, Michiko
AU - Shibata, Shigenobu
AU - Watanabe, Shigenori
N1 - Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1998/11/6
Y1 - 1998/11/6
N2 - The suprachiasmatic nucleus (SCN) has been identified as a pacemaker for mammalian circadian rhythms. Excitatory amino acid receptors, especially N- methyl-D-aspartate (NMDA) receptors, have been considered to play an important role in the transmission of light information from the retina to the circadian clocks in the SCN. In the present study, we showed that application of NMDA at circadian time (CT) 12-15 induced significant glutamate release from the SCN region in vitro. The NMDA-induced glutamate release was blocked by co-application of the NMDA receptor antagonist MK- 801, but not by that of tetrodotoxin. These results suggested that glutamate stimulated its own release by activating NMDA receptors. This NMDA-induced glutamate release through NMDA receptor-mediated mechanisms might be involved in NMDA-induced potent phase shifts.
AB - The suprachiasmatic nucleus (SCN) has been identified as a pacemaker for mammalian circadian rhythms. Excitatory amino acid receptors, especially N- methyl-D-aspartate (NMDA) receptors, have been considered to play an important role in the transmission of light information from the retina to the circadian clocks in the SCN. In the present study, we showed that application of NMDA at circadian time (CT) 12-15 induced significant glutamate release from the SCN region in vitro. The NMDA-induced glutamate release was blocked by co-application of the NMDA receptor antagonist MK- 801, but not by that of tetrodotoxin. These results suggested that glutamate stimulated its own release by activating NMDA receptors. This NMDA-induced glutamate release through NMDA receptor-mediated mechanisms might be involved in NMDA-induced potent phase shifts.
KW - Circadian rhythm
KW - Glutamates
KW - N-Methyl-D- aspartate
KW - Rat
KW - Suprachiasmatic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0032491532&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032491532&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(98)00762-9
DO - 10.1016/S0304-3940(98)00762-9
M3 - Article
C2 - 9853711
AN - SCOPUS:0032491532
SN - 0304-3940
VL - 256
SP - 93
EP - 96
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 2
ER -