Nucleotide Sequence and Chromosomal Mapping of the Human c‐yes‐2 Gene

Kentaro Semba*, Makoto Nishizawa, Hitoshi Satoh, Shin‐ichi ‐i Fukushige, Michihiro C. Yoshida, Motomichi Sasaki, Ken‐ichi ‐i Marsusbra, Tadashi Yamamoto, Kumao Toyoshima

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We molecularly characterized the second gene, c‐yes‐2, of two copies of yes‐related genes which we previously found to contain in the human genome. First, nucleotide sequence analysis revealed that the c‐yes‐2 gene is a pseudogene of the c‐yes‐1 gene. Second, by using two independent methods, hybridization of both DNAs from sorted chromosomes and metaphase spreads with c‐yes‐2 DNA, we assigned the c‐yes‐2 gene to chromosome 22q11.2. This chromosomal localization is inconsistent with that given in our previous report. The failure of proper mapping in our experiment might have been caused by instability of hybrid cell clones.

Original languageEnglish
Pages (from-to)710-717
Number of pages8
JournalJapanese Journal of Cancer Research
Issue number6
Publication statusPublished - 1988 Jun
Externally publishedYes


  • Chromosome 22
  • Pseudogene
  • c‐yes‐2

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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