Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase

Kazuhiko Uchida*, Toshiro Morita, Takako Sato, Tsutomu Ogura, Rumiko Yamashita, Shigeru Noguchi, Hisanori Suzuki, Hiroshi Nyunoya, Masanao Miwa, Takashi Sugimura

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)


The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.

Original languageEnglish
Pages (from-to)617-622
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1987 Oct 29
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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