TY - JOUR
T1 - Nucleotide sequence of a full-length cDNA for human fibroblast poly(ADP-ribose) polymerase
AU - Uchida, Kazuhiko
AU - Morita, Toshiro
AU - Sato, Takako
AU - Ogura, Tsutomu
AU - Yamashita, Rumiko
AU - Noguchi, Shigeru
AU - Suzuki, Hisanori
AU - Nyunoya, Hiroshi
AU - Miwa, Masanao
AU - Sugimura, Takashi
N1 - Funding Information:
We wish to thank Dr. H. Okayama for supplying the pcDGM637 cDNA library and Drs. S. Nagata, M. Yamada, M. Terada, M. Nagao, K. Shimotohno, T. Yoshida and H. Shima for valuable suggestions. This work was supported in part by a grant for Cancer Research from the Ministry of Education, Science and Culture, and a Grant-in-Aid from the Ministry of Health and Welfare for the Comprehensive lo-Year Strategy for Cancer Control, Japan. K.U., T.M., T.O. and S.N. are Awardees of Research Resident Fellowships and H.S. is an Awardee of a Foreign Research Fellowship from the Foundation for Promotion of Cancer Research.
PY - 1987/10/29
Y1 - 1987/10/29
N2 - The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
AB - The complete nucleotide sequence of human fibroblast poly(ADP-ribose) polymerase cDNA was determined. The cDNA contains an open reading frame for a 1014 amino acid polypeptide. In the DNA binding domain of poly(ADP-ribose) polymerase, there are predicted α-helix-turn-α-helix structures and two sequences each of about 100 amino acids that are similar to each other containing potential cysteine-zinc DNA binding structures. Within the 3′ untranslated region, there is an AT-rich sequence containing ATTTA, a possible mRNA destabilizer.
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U2 - 10.1016/0006-291X(87)90921-1
DO - 10.1016/0006-291X(87)90921-1
M3 - Article
C2 - 3120710
AN - SCOPUS:0023200519
SN - 0006-291X
VL - 148
SP - 617
EP - 622
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -