Nutrition and Diet as Potent Regulators of the Liver Clock

Yu Tahara*, Shigenobu Shibata

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


This chapter centers on the new keyword "chrono-nutrition", which helps to understand the importance of mutual interactions between circadian rhythms and nutrition/diet. The timing of food can have a major impact on the circadian system. The "food entrainable oscillator" (FEO) senses food timing and/or nutritional factors, and then organizes the circadian system independent of suprachiasmatic nucleus (SCN) regulation. To understand the mechanism of FEO, many types of food have been used for food-induced phase entrainment in the circadian system. Food-induced insulin secretion is an important direct pathway for food entrainment in the liver circadian clock. The chapter also highlights the interactions between food, circadian system, and disease. Regular meal time has the possibility to improve the deficit of the circadian system, independent of the master clock function. Food can become a "zeitgeber" to entrain the circadian system and it is hoped that eating times function as a "zeitgeber" in humans.

Original languageEnglish
Title of host publicationCircadian Medicine
Number of pages11
ISBN (Electronic)9781118467831
ISBN (Print)9781118467787
Publication statusPublished - 2015 May 8
Externally publishedYes


  • Circadian rhythm
  • Food entrainable oscillator (FEO)
  • Liver clock
  • Nutrition
  • Potent regulators
  • Suprachiasmatic nucleus (SCN)
  • Zeitgeber

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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