On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity

Kenji Yasuda

doi:10.1109/EMBC.2013.6610128

On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity

Kenji Yasuda^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

Original language	English
Title of host publication	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Pages	2825-2828
Number of pages	4
DOIs	https://doi.org/10.1109/EMBC.2013.6610128
Publication status	Published - 2013 Oct 31
Externally published	Yes
Event	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 - Osaka, Japan Duration: 2013 Jul 3 → 2013 Jul 7

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
ISSN (Print)	1557-170X

Other

Other	2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013
Country/Territory	Japan
City	Osaka
Period	13/7/3 → 13/7/7

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Access to Document

10.1109/EMBC.2013.6610128

Cite this

Yasuda, K. (2013). On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 (pp. 2825-2828). [6610128] (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). https://doi.org/10.1109/EMBC.2013.6610128

On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. / Yasuda, Kenji.
2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2825-2828 6610128 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Yasuda, K 2013, On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. in 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013., 6610128, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, pp. 2825-2828, 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013, Osaka, Japan, 13/7/3. https://doi.org/10.1109/EMBC.2013.6610128

Yasuda K. On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. In 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. p. 2825-2828. 6610128. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC.2013.6610128

Yasuda, Kenji. / On-chip cellomics : Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013. 2013. pp. 2825-2828 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

@inproceedings{fb414c42899043519602caf96c95822e,

title = "On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity",

abstract = "We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.",

author = "Kenji Yasuda",

year = "2013",

month = oct,

day = "31",

doi = "10.1109/EMBC.2013.6610128",

language = "English",

isbn = "9781457702167",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

pages = "2825--2828",

booktitle = "2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013",

note = "2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013 ; Conference date: 03-07-2013 Through 07-07-2013",

}

TY - GEN

T1 - On-chip cellomics

T2 - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013

AU - Yasuda, Kenji

PY - 2013/10/31

Y1 - 2013/10/31

N2 - We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

AB - We have developed methods and systems of analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. A system of analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). As an example of the 'geometric' system, we have developed an quasi-in vivo hiPS cardiomyocyte network assay and confirmed that it can predict the risk of lethal arrythmia correctly in 22 compounds. The knowlege acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.

UR - http://www.scopus.com/inward/record.url?scp=84886497081&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84886497081&partnerID=8YFLogxK

U2 - 10.1109/EMBC.2013.6610128

DO - 10.1109/EMBC.2013.6610128

M3 - Conference contribution

C2 - 24110315

AN - SCOPUS:84886497081

SN - 9781457702167

T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

SP - 2825

EP - 2828

BT - 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC 2013

Y2 - 3 July 2013 through 7 July 2013

ER -

On-chip cellomics: Single-cell-based constructive cell-network assay for quasi-in vivo screening of cardiotoxicity

Abstract

Publication series

Other

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this