On robust stability and sensitivity of circadian rhythms

Kazuto Ogawa*, Nao Takekawa, Kenko Uchida, Shigenobu Shibata

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


We develop an approach to the robustness analysis of circadian rhythms from the viewpoints of (local) robust stability of periodic trajectories and their period-sensitivity, based on mathematical models. Our attention is directed to the core molecular model generating circadian rhythms in Drosophila, proposed by Goldbeter [1], for our approach to be illustrated. We consider two cases when the circadian rhythms are subjected to periodic forcing by light/dark (LD) cycles and when the circadian rhythms are under continuous darkness (DD). First, we propose conditions/algorithms for (local) robust stability, and it is shown that the circadian rhythms generated by the core molecular model are (locally) robustly stable, in both LD and DD cases. Second, in DD case, we derive a formula of period sensitivity, and assess the effects of (infinitesimal) parameter-variations on the period of the circadian rhythms.

Original languageEnglish
Pages (from-to)281-289
Number of pages9
JournalAsian Journal of Control
Issue number3
Publication statusPublished - 2006 Sept


  • Circadian rhythm
  • Molecular model
  • Period sensitivity
  • Periodic trajectory
  • Robust stability

ASJC Scopus subject areas

  • Control and Systems Engineering


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