TY - JOUR
T1 - On the injectability of free-standing magnetic nanofilms
AU - Taccola, Silvia
AU - Pensabene, Virginia
AU - Fujie, Toshinori
AU - Takeoka, Shinji
AU - Pugno, Nicola M.
AU - Mattoli, Virgilio
N1 - Funding Information:
Acknowledgement This work was supported in part by JFE (The Japanese Foundation for Research and Promotion of Endoscopy) Grant (T.F.). JSPS KAKENHI (grant number 15H05355 for T.F., 16K14009 for S.T.) from MEXT, Japan, and the Precursory Research for Embryonic Science and Technology (PRESTO) from the Japan Science and Technology Agency (JST) (grant number JPMJPR152A for T.F.). Nicola M. Pugno is supported by the European Research Council PoC 2015 BSilkene^ No. 693670, by the European Commission H2020 under the Graphene Flagship Core 1 No. 696656 (WP14 BPolymer Nanocomposites^) and under the FET Proactive BNeurofibres^ No. 732344.
Publisher Copyright:
© 2017, Springer Science+Business Media New York.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Our results show that these freely suspended nanocomposite nanofilms are highly flexible and deformable, with Young’s moduli of few GPa. Since they can be handled in liquid with syringes, a quantitative description of the nanofilms behavior during the manipulation with clinically applicable needles has been also provided. These magnetic nanofilms, remotely controllable by external electromagnetic fields, have potential applications in minimally invasive surgery as injectable nanopatches on inner organs wall. [Figure not available: see fulltext.].
AB - Free-standing films with sub-micrometric thickness, composed of soft polymers and functional nanostructures are promising candidates for many potential applications in the biomedical field, such as reduced port abdominal surgery. In this work, freely suspended poly(L-lactic acid) nanofilms with controlled morphology embedding superparamagnetic iron oxide nanoparticles were fabricated by spin-coating deposition. The mechanical properties of magnetic nanofilms were investigated by Strain-Induced Elastic Buckling Instability for Mechanical Measurements (SIEBIMM) test. Our results show that these freely suspended nanocomposite nanofilms are highly flexible and deformable, with Young’s moduli of few GPa. Since they can be handled in liquid with syringes, a quantitative description of the nanofilms behavior during the manipulation with clinically applicable needles has been also provided. These magnetic nanofilms, remotely controllable by external electromagnetic fields, have potential applications in minimally invasive surgery as injectable nanopatches on inner organs wall. [Figure not available: see fulltext.].
KW - Injectability
KW - Magnetic nanocomposite
KW - Minimally invasive surgery
KW - Nanofilm
KW - Nanopatch
KW - SIEBIMM
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U2 - 10.1007/s10544-017-0192-1
DO - 10.1007/s10544-017-0192-1
M3 - Article
C2 - 28577265
AN - SCOPUS:85028361494
SN - 1387-2176
VL - 19
JO - Biomedical Microdevices
JF - Biomedical Microdevices
IS - 3
M1 - 51
ER -