One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

Takanori Shibata; Tadakatsu Hayase; Jun Yamamoto; Kenso Soai

doi:10.1016/S0957-4166(97)00183-3

One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

Takanori Shibata, Tadakatsu Hayase, Jun Yamamoto, Kenso Soai^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

69 Citations (Scopus)

Abstract

A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.

Original language	English
Pages (from-to)	1717-1719
Number of pages	3
Journal	Tetrahedron Asymmetry
Volume	8
Issue number	11
DOIs	https://doi.org/10.1016/S0957-4166(97)00183-3
Publication status	Published - 1997 Jun 12
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess",

abstract = "A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.",

author = "Takanori Shibata and Tadakatsu Hayase and Jun Yamamoto and Kenso Soai",

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T1 - One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

AU - Shibata, Takanori

AU - Hayase, Tadakatsu

AU - Yamamoto, Jun

AU - Soai, Kenso

PY - 1997/6/12

Y1 - 1997/6/12

N2 - A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.

AB - A trace amount (ca. 3 mg) of 2-methylpyrimidyl alkanol with only a slight enantiomeric excess (0.2-0.3% e.e.) was auto-multiplied with dramatic amplification of enantiomeric excess (up to ca. 90% e.e.) in one-pot asymmetric autocatalytic reaction using diisopropylzinc and 2-methylpyrimidine-5-carbaldehyde.

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U2 - 10.1016/S0957-4166(97)00183-3

DO - 10.1016/S0957-4166(97)00183-3

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JO - Tetrahedron Asymmetry

JF - Tetrahedron Asymmetry

IS - 11

ER -

One-pot asymmetric autocatalytic reaction with remarkable amplification of enantiomeric excess

Abstract

ASJC Scopus subject areas

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