One-Pot Fabrication of Dendritic NiO@carbon-nitrogen Dot Electrodes for Screening Blood Glucose Level in Diabetes

Naeem Akhtar, Sherif A. El-Safty*, Mamdouh E. Abdelsalam, Hiroshi Kawarada

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Selective and sensitive glucose sensors with fast response for screening diabetic blood level are demanded. In this paper, the one-pot nanoarchitecture of dendritic NiO@carbon-nitrogen (C-N) dots (designated as NCD) sphere-wrapping Ni foam electrodes are reported as an effective and sensitive glucose sensor in blood samples. In this construction design, the NCD sphere electrode with excessive surface defects, large fractions of catalytic active sites, high surface area, and mobility of electron transfer through the actively surface NCD sphere can massively enhance the electrocatalytic activity for nonenzymatic glucose detection in diabetic blood. This portable sensor enables highly sensitive recognition of glucose detection (≈0.01 × 10-6m) over a wider linear range (≈0.005-12 × 10-3m) with rapid response time of a few seconds. The key result is that the engineered NCD sphere electrodes function as simple, easy-to-use electrochemical sensing assays of glucose levels in diabetic blood patients with a wide range of precision or linearity, recyclability, and excellent selectivity, even in the presence of potentially interfering organic (ascorbic acid, uric acid, dopamine, lactose, maltose, and sucrose) and inorganic (NaCl, Na2SO4, KCl, and K2SO4) species. The results demonstrate the potential for the electrochemical sensors to be used in preventing serious health problems associated with diabetes mismanagement.

Original languageEnglish
Pages (from-to)2110-2119
Number of pages10
JournalAdvanced Healthcare Materials
Issue number14
Publication statusPublished - 2015 Oct 7


  • Diabetic blood
  • Electrodes, electrochemical sensors
  • Glucose sensors
  • NiO@carbon-nitrogen dot

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Pharmaceutical Science


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