Onto-biology: Clarifying the spatiotemporal structure

Ken Naitoh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


This article outlines a protocol describing the origin and evolution of life which is based on the seven principles of (I) information, (II) function, (III) topology, (IV) metabolism, (V) diversity, (VI) cycle, and (VII) discontinuity. One-dimensional information induces three-dimensional topologies of molecules such as RNA and proteins, which lead to various functions. Diversity and discontinuity principles clarify the fusion of only 20 amino acids and diverse proteins. Then metabolic cycles induced by input energy promote continuous replications of information and functions. The protocol is derived based on the nonstatic quantum mechanics of time-dependent electron clouds, thermo-fluid dynamics, stochastic mechanics, chemistry, and fundamental mathematics as the warp, and on biological research related to molecular biology, morphogenesis, bioinformatics, the origin of life, and medicine as the weft. Several natural processes, including the prebiotic soup, first cells, prokaryotes, eukaryotes, and mammals, can be generated by repeating the seven steps representing the seven principles in this protocol.

Original languageEnglish
Pages (from-to)117-127
Number of pages11
JournalArtificial Life and Robotics
Issue number1
Publication statusPublished - 2010 Sept 6


  • Design diagram
  • Morphogenesis
  • Origin
  • Protocol
  • Seven principles

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology
  • Artificial Intelligence


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