OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE: THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.

Makoto Yuasa; Etsuo Hasegawa; Hiroyuki Nishide; Eishun Tsuchida

OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE: THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.

Makoto Yuasa^*, Etsuo Hasegawa, Hiroyuki Nishide, Eishun Tsuchida

^*Corresponding author for this work

Waseda Research Institute for Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.

Original language	English
Pages (from-to)	661-668
Number of pages	8
Journal	Journal of macromolecular science. Chemistry
Volume	A24
Issue number	6
Publication status	Published - 1987

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE: THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.",

abstract = "An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.",

author = "Makoto Yuasa and Etsuo Hasegawa and Hiroyuki Nishide and Eishun Tsuchida",

year = "1987",

language = "English",

volume = "A24",

pages = "661--668",

journal = "Journal of Macromolecular Science - Pure and Applied Chemistry",

issn = "1060-1325",

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T1 - OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE

T2 - THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.

AU - Yuasa, Makoto

AU - Hasegawa, Etsuo

AU - Nishide, Hiroyuki

AU - Tsuchida, Eishun

PY - 1987

Y1 - 1987

N2 - An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.

AB - An oxygen-supplying medium (OSM), which was prepared by embedding a synthetic heme complex in a bilayer of polymerized lipid liposome (polylipid liposome/heme), could blind molecular oxygen reversibly under physiological conditions. The oxygen-exchange reaction of OSM with blood was examined by using a liquid/liquid artificial lung device. For example, deoxy-blood (p//S(O//2) equals 0 torr) was passed countercurrent to oxy-OSM (p//S(O//2) equals 154 torr) through hollow fibers of the device to provide oxy-blood (p//b(O//2) equals 57 torr). The OSM was physicochemically and mechanically stable under strong shear stress during the passage through the hollow fibers and acted as the oxygen mediator to blood.

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JF - Journal of Macromolecular Science - Pure and Applied Chemistry

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OXYGEN-EXCHANGE REACTION BETWEEN ARTIFICIAL LUNG DEVICE: THE HEME EMBEDDED IN POLYMERIZED LIPO LIPOSOME AS AN ARTIFICIAL OXYGEN CARRIER.

Abstract

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