Oxygen permeability of biodegradable copolycaprolactones

Shenguo Wang; Hiroyuki Nishide; Eishun Tsuchida

Oxygen permeability of biodegradable copolycaprolactones

Shenguo Wang, Hiroyuki Nishide, Eishun Tsuchida^*

^*Corresponding author for this work

Waseda Research Institute for Science and Engineering

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10^-10 ∼ 10^-9 cm³ (STP) cm/cm² sec cm Hg. Copolymers PCE and PCEL displayed O₂ and N₂ permeability coefficients (PO₂/PN₂) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.

Original language	English
Pages (from-to)	282-286
Number of pages	5
Journal	Polymers for Advanced Technologies
Volume	10
Issue number	5
Publication status	Published - 1999 May

Keywords

Biodegradability
Copolymer
Oxygen permeability
Polycaprolactone

ASJC Scopus subject areas

Polymers and Plastics

Cite this

@article{1e8c396f3ebc4f6dbd191ee429537bec,

title = "Oxygen permeability of biodegradable copolycaprolactones",

abstract = "Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10-10 ∼ 10-9 cm3 (STP) cm/cm2 sec cm Hg. Copolymers PCE and PCEL displayed O2 and N2 permeability coefficients (PO2/PN2) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.",

keywords = "Biodegradability, Copolymer, Oxygen permeability, Polycaprolactone",

author = "Shenguo Wang and Hiroyuki Nishide and Eishun Tsuchida",

year = "1999",

month = may,

language = "English",

volume = "10",

pages = "282--286",

journal = "Polymers for Advanced Technologies",

issn = "1042-7147",

publisher = "John Wiley and Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Oxygen permeability of biodegradable copolycaprolactones

AU - Wang, Shenguo

AU - Nishide, Hiroyuki

AU - Tsuchida, Eishun

PY - 1999/5

Y1 - 1999/5

N2 - Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10-10 ∼ 10-9 cm3 (STP) cm/cm2 sec cm Hg. Copolymers PCE and PCEL displayed O2 and N2 permeability coefficients (PO2/PN2) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.

AB - Polycaprolactone is one of the biodegradable polymers with good drug permeability. In the present paper, polycaprolactone and three kinds of copolycaprolactone-polycaprolactone-poly(ethylene oxide)-polycaprolactone triblock copolymer (PCE), polycaprolactone/polycaprolactone-poly(ethylene oxide)/polylactide tricomponents random block copolymer (PCEL) and polycaprolactone/ poly(ethylene terephthalate) random block copolymer (PETCL)-were synthesized. The biodegradation behavior of these polymers were shown by degradation tests in vitro, ex vivo and in vivo. The oxygen permeabilities of these polymers were in the range of 10-10 ∼ 10-9 cm3 (STP) cm/cm2 sec cm Hg. Copolymers PCE and PCEL displayed O2 and N2 permeability coefficients (PO2/PN2) ratios of about 9. The effects of composition and crystallinity of the copolymers on biodegradability and the oxygen permeability of the polymer were discussed.

KW - Biodegradability

KW - Copolymer

KW - Oxygen permeability

KW - Polycaprolactone

UR - http://www.scopus.com/inward/record.url?scp=0006314785&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0006314785&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0006314785

SN - 1042-7147

VL - 10

SP - 282

EP - 286

JO - Polymers for Advanced Technologies

JF - Polymers for Advanced Technologies

IS - 5

ER -

Oxygen permeability of biodegradable copolycaprolactones

Abstract

Keywords

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this