TY - JOUR
T1 - Oxygen-transport and solution properties of polylipid/hb vesicles (arc)
AU - Takeoka, Shinji
AU - Hasegawa, Etsuo
AU - Nishide, Hiroyuki
AU - Tsuchida, Eishun
AU - Sekiguchi, Sadayoshi
PY - 1992/1
Y1 - 1992/1
N2 - Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by y-ray irradiation. The average radius of resulting vesicles was 203 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. y-Ray polymerization proceeds theoretically at low temperature (4C). Pso and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.
AB - Polymerized phospholipid vesicle encapsulating Hb (polylipid/Hb vesicle) was prepared from a mixture of unsaturated phospholipid, cholesterol and unsaturated fatty acid and polymerization by y-ray irradiation. The average radius of resulting vesicles was 203 39 nm and concentrated Hb (30 wt%) was efficiently encapsulated. y-Ray polymerization proceeds theoretically at low temperature (4C). Pso and oxygen transporting efficiency were adjusted to 40 mmHg and 40%, respectively. Oncotic pressure and solution viscosity can be controlled to the same values as blood.
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U2 - 10.3109/10731199209119659
DO - 10.3109/10731199209119659
M3 - Article
C2 - 1391455
AN - SCOPUS:0026761161
SN - 1055-7172
VL - 20
SP - 399
EP - 404
JO - Biomaterials, Artificial Cells and Immobilization Biotechnology
JF - Biomaterials, Artificial Cells and Immobilization Biotechnology
IS - 4 --Feb
ER -