Palladium-catalyzed decarbonylative alkynylation of aromatic esters

Toshimasa Okita, Kazushi Kumazawa, Ryosuke Takise, Kei Muto, Kenichiro Itami*, Junichiro Yamaguchi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


A palladium-catalyzed decarbonylative alkynylation reaction of aromatic esters with terminal alkynes is reported. This reaction allows for halogen-free Sonogashira coupling, resulting in various aryl- and heteroarylalkynes. The utility of the reaction was demonstrated by orthogonal coupling reaction.

Original languageEnglish
Pages (from-to)218-220
Number of pages3
JournalChemistry Letters
Issue number2
Publication statusPublished - 2017


  • Alkyne
  • Decarbonylative reaction
  • Palladium

ASJC Scopus subject areas

  • General Chemistry


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