Partial Seeding Policy for Controlling the Crystal Quality in Batch Cooling Crystallization

Joi Unno*, Izumi Hirasawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Partial seeding, in which the nuclei originating from seed crystals grow to yield the product crystals, was simulated and optimized for controlling the batch cooling crystallization process of L-arginine. The product quality was evaluated by the coefficient of variation (CV) of the crystal size distribution. First, the optimum seed amount for partial seeding was estimated by simulation. Then, the simulated values of the optimum seed amount and the resulting local minimum CV were correlated with the seed crystal size and the cooling rate. The correlation can be utilized for estimating the seed amount in the case that the seed crystals are added in a slurry. Finally, these simulated values were compared to the measured ones. Consequently, the optimum seed amount was suggested to be reasonably predicted.

Original languageEnglish
Pages (from-to)1065-1071
Number of pages7
JournalChemical Engineering and Technology
Issue number6
Publication statusPublished - 2020 Jun 1


  • Crystallization
  • Particle size
  • Process control
  • Seed crystals
  • Simulation

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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