TY - JOUR
T1 - Pentraxin 3 increases in adult overweight and obese men after weight loss by dietary modification with exercise training
AU - Zempo-Miyaki, Asako
AU - Kumagai, Hiroshi
AU - Yoshikawa, Toru
AU - Myoenzono, Kanae
AU - So, Rina
AU - Otsuki, Takeshi
AU - Tanaka, Kiyoji
AU - Maeda, Seiji
N1 - Funding Information:
This work was supported by Grants-in-Aid for Scientific Research 15K16519 from the Japan Society for the Promotion of Science and the Meiji Yasuda Life Foundation of Health and Welfare.
Publisher Copyright:
© 2019, Canadian Science Publishing. All rights reserved.
PY - 2019
Y1 - 2019
N2 - The circulatory level of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, has been shown to be lower in obese individuals than in those with normal weight. However, reports on the effects of different weight-loss methods on PTX3 are limited. The present study aimed to investigate the effect of weight loss on circulating PTX3 levels in overweight and obese men and to examine the combined effect of dietary modification and exercise training on PTX3 levels. Forty-eight overweight and obese men were assigned to 2 groups: dietary modification (group D) or exercise training and dietary modification (group DE). Groups D and DE were composed of 27 and 21 participants, respectively. We observed a significant independent relationship between changes in PTX3 and body mass index (BMI) in all participants (β = −0.617, p < 0.01). Subsequently, we compared the effects of the 2 weight-loss methods on plasma PTX3 in groups D and DE. The magnitude of the increase in plasma PTX3 levels was similar in the 2 groups. Interestingly, we observed that PTX3 levels in group DE increased significantly more than those in group D in subjects who achieved normal weight, based on BMI, after interventions. Our study suggested that weight reduction after lifestyle modification significantly increased PTX3 levels in overweight and obese men, and the addition of habitual exercise to dietary modification enhanced the magnitude of the increase in PTX3 levels in obese individuals achieving normal weight after weight loss.
AB - The circulatory level of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, has been shown to be lower in obese individuals than in those with normal weight. However, reports on the effects of different weight-loss methods on PTX3 are limited. The present study aimed to investigate the effect of weight loss on circulating PTX3 levels in overweight and obese men and to examine the combined effect of dietary modification and exercise training on PTX3 levels. Forty-eight overweight and obese men were assigned to 2 groups: dietary modification (group D) or exercise training and dietary modification (group DE). Groups D and DE were composed of 27 and 21 participants, respectively. We observed a significant independent relationship between changes in PTX3 and body mass index (BMI) in all participants (β = −0.617, p < 0.01). Subsequently, we compared the effects of the 2 weight-loss methods on plasma PTX3 in groups D and DE. The magnitude of the increase in plasma PTX3 levels was similar in the 2 groups. Interestingly, we observed that PTX3 levels in group DE increased significantly more than those in group D in subjects who achieved normal weight, based on BMI, after interventions. Our study suggested that weight reduction after lifestyle modification significantly increased PTX3 levels in overweight and obese men, and the addition of habitual exercise to dietary modification enhanced the magnitude of the increase in PTX3 levels in obese individuals achieving normal weight after weight loss.
KW - Inflammation
KW - Obesity
KW - PTX3
KW - Weight loss
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U2 - 10.1139/apnm-2018-0214
DO - 10.1139/apnm-2018-0214
M3 - Article
C2 - 29990442
AN - SCOPUS:85060843012
SN - 1715-5312
VL - 44
SP - 111
EP - 117
JO - Applied Physiology, Nutrition and Metabolism
JF - Applied Physiology, Nutrition and Metabolism
IS - 2
ER -
