Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Xuetao Shi; Toshinori Fujie; Akihiro Saito; Shinji Takeoka; Ying Hou; Yiwei Shu; Mingwei Chen; Hongkai Wu; Ali Khademhosseini

doi:10.1002/adma.201305804

Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Xuetao Shi, Toshinori Fujie, Akihiro Saito, Shinji Takeoka, Ying Hou, Yiwei Shu, Mingwei Chen, Hongkai Wu^*, Ali Khademhosseini

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

90 Citations (Scopus)

Abstract

A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.

Original language	English
Pages (from-to)	3290-3296
Number of pages	7
Journal	Advanced Materials
Volume	26
Issue number	20
DOIs	https://doi.org/10.1002/adma.201305804
Publication status	Published - 2014 May 28

Keywords

adhesiveness
bone repair
micropattern
nanosheet
periosteum

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.1002/adma.201305804

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AU - Fujie, Toshinori

AU - Saito, Akihiro

AU - Takeoka, Shinji

AU - Hou, Ying

AU - Shu, Yiwei

AU - Chen, Mingwei

AU - Wu, Hongkai

AU - Khademhosseini, Ali

PY - 2014/5/28

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AB - A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.

KW - adhesiveness

KW - bone repair

KW - micropattern

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KW - periosteum

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Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Abstract

Keywords

ASJC Scopus subject areas

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