Periosteum-mimetic structures made from freestanding microgrooved nanosheets

Xuetao Shi, Toshinori Fujie, Akihiro Saito, Shinji Takeoka, Ying Hou, Yiwei Shu, Mingwei Chen, Hongkai Wu*, Ali Khademhosseini

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

90 Citations (Scopus)


A "sticker-like" PLGA nanosheet with microgrooved patterns is developed through a facile combination of spin coating and micropatterning techniques. The resulting microgrooved PLGA nanosheets can be physically adhered on flat or porous surfaces with excellent stability in aqueous environments and can harness the spatial arrangements of cells, which make it a promising candidate for generating biomimic periosteum for bone regenerative applications.

Original languageEnglish
Pages (from-to)3290-3296
Number of pages7
JournalAdvanced Materials
Issue number20
Publication statusPublished - 2014 May 28


  • adhesiveness
  • bone repair
  • micropattern
  • nanosheet
  • periosteum

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering


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