TY - JOUR
T1 - pH-Sensitive liposome retaining Fe-porphyrin as SOD mimic for novel anticancer drug delivery system
AU - Kawakami, Hiroyoshi
AU - Hiraka, Kazue
AU - Tamai, Miho
AU - Horiuchi, Aiko
AU - Ogata, Akihiko
AU - Hatsugai, Tomomi
AU - Yamaguchi, Aritomo
AU - Oyaizu, Kenichi
AU - Yuasa, Makoto
PY - 2007/1
Y1 - 2007/1
N2 - In this article the novel design of an anticancer drug delivery system is reported based on a pH-sensitive liposome retaining the Fe-porphyrin as a superoxide dismutase(SOD) mimic. The liposomes contained cationic/ anionic lipid combinations and were composed of Fe-porphyrin, L-α-phosphatidylcholine (DMPC), dimethylditetradecylammonium bromide (DTDAB), sodispdum oleate (OANa), and Tween-80. The size of the liposome was approximately 30 nm. The EC50 value (the effective concentration of compound required to produce a 50% lethal dose against cells) of the liposome was found to be significantly smaller than that of cisplatin as the control drug, suggesting that the liposome showed a high cytotoxicity toward the cancer cells. This is due to the fact that the pH-sensitive liposome rapidly corresponds to the acidic environments of the endosomes and is unstable, and the Fe-porphyrin is delivered into the cytosol. This result suggests that O2- may be useful as a target molecule to induce the selective death of cancer cells and that a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic is a new class of anticancer agent.
AB - In this article the novel design of an anticancer drug delivery system is reported based on a pH-sensitive liposome retaining the Fe-porphyrin as a superoxide dismutase(SOD) mimic. The liposomes contained cationic/ anionic lipid combinations and were composed of Fe-porphyrin, L-α-phosphatidylcholine (DMPC), dimethylditetradecylammonium bromide (DTDAB), sodispdum oleate (OANa), and Tween-80. The size of the liposome was approximately 30 nm. The EC50 value (the effective concentration of compound required to produce a 50% lethal dose against cells) of the liposome was found to be significantly smaller than that of cisplatin as the control drug, suggesting that the liposome showed a high cytotoxicity toward the cancer cells. This is due to the fact that the pH-sensitive liposome rapidly corresponds to the acidic environments of the endosomes and is unstable, and the Fe-porphyrin is delivered into the cytosol. This result suggests that O2- may be useful as a target molecule to induce the selective death of cancer cells and that a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic is a new class of anticancer agent.
KW - Drug delivery systems
KW - Fe-porphyrin
KW - Nanoparticles
KW - pH-Sensitive liposome
UR - http://www.scopus.com/inward/record.url?scp=33846671782&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846671782&partnerID=8YFLogxK
U2 - 10.1002/pat.855
DO - 10.1002/pat.855
M3 - Article
AN - SCOPUS:33846671782
SN - 1042-7147
VL - 18
SP - 82
EP - 87
JO - Polymers for Advanced Technologies
JF - Polymers for Advanced Technologies
IS - 1
ER -
