Pharmaceutical study on circadian rhythms in mammals

S. Shibata*, S. Watanabe

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Living organisms including humans drive circadian rhythm, and this rhythm influences the social structure and daily life of human beings. The suprachiasmatic nucleus (SCN) has been established as a pacemaker for mammalian circadian rhythm. There are many kinds of neurotransmitters and neuromodulators in this nucleus. The circadian systems are involved in oscillation, input (entrainment) and output (overt rhythm). Therefore in this review, pharmacological characteristics of circadian systems in relation to the SCN are discussed by focussing especially upon the roles of various neurotransmitters and modulators.

Original languageEnglish
Pages (from-to)637-654
Number of pages18
JournalYakugaku Zasshi
Issue number9
Publication statusPublished - 1994
Externally publishedYes


  • biological clock
  • circadian rhythm
  • entrainment
  • oscillation
  • pharmacology
  • suprachiasmatic nucleus

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science


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