Phase-resetting response to (+)8-OH-DPAT, a serotonin 1A/7 receptor agonist, in the mouse in vivo

Kazumasa Horikawa, Shigenobu Shibata

Research output: Contribution to journalArticlepeer-review

47 Citations (Scopus)


Several lines of evidence indicate that 5-HT neuronal systems may play a critical role for the non-photic entrainment of the rodent circadian clock. Although it is well established that (+)8-hydroxy-2-(di-n-propylamino)tetralin [(+)8-OH-DPAT], a 5-HT 1A/7 receptor agonist, causes a phase-advance of behavioral rhythm in hamsters, little is known whether this agent produces phase shifts of activity rhythm in mice. Therefore, we examined the effect of (+)8-OH-DPAT on the mouse locomotor activity rhythm. Systemic administration of this chemical at mid-subjective daytime induced a clear and dose-dependent phase advance, while there were no significant phase shifts at other times (early-subjective day, late-subjective day, or subjective night). Additionally, (+)8-OH-DPAT accelerated the re-entrainment of mouse behavioral rhythm to a 6-h advanced light-dark cycle. These results suggest that we can use mice for understanding the molecular mechanism of (+)8-OH-DPAT-induced phase shift because of availability of clock gene targeted mice.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalNeuroscience Letters
Issue number2
Publication statusPublished - 2004 Sept 23


  • (+)8-OH-DPAT
  • 5-HT receptor
  • Circadian rhythm
  • Mouse
  • Phase shift
  • Serotonin

ASJC Scopus subject areas

  • Neuroscience(all)


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