TY - JOUR
T1 - Phosphocholine-substituted 5,10,15,20-tetraphenylporphyrinatoiron(II)
T2 - Oxygen carrier under physiological conditions
AU - Tsuchida, Eishun
AU - Nishide, Hiroyuki
AU - Yuasa, Makoto
AU - Hasegawa, Etsuo
AU - Matsushita, Yoh ichi
AU - Eshima, Kiyoshi
PY - 1985
Y1 - 1985
N2 - A novel and amphiphilic 5,10,15,20-tetraphenylporphyrinatoiron complex substituted with phosphocholine groups, 5,10,15,20-tetra{α,α,α,α-o- [2′,2′-dimethyl-20′-(2″-trimethylammonioethyl phosphonatoxy)eicosanamido]phenyl}porphyrinatoiron(II) (lipid-heme), has been synthesized. The lipid-heme formed a stable liposome with a phospholipid. The liposomal lipid-heme reversibly bound oxygen in neutral aqueous media at 37 °C, and its oxygen-binding rate and affinity were similar to those of red blood cells.
AB - A novel and amphiphilic 5,10,15,20-tetraphenylporphyrinatoiron complex substituted with phosphocholine groups, 5,10,15,20-tetra{α,α,α,α-o- [2′,2′-dimethyl-20′-(2″-trimethylammonioethyl phosphonatoxy)eicosanamido]phenyl}porphyrinatoiron(II) (lipid-heme), has been synthesized. The lipid-heme formed a stable liposome with a phospholipid. The liposomal lipid-heme reversibly bound oxygen in neutral aqueous media at 37 °C, and its oxygen-binding rate and affinity were similar to those of red blood cells.
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U2 - 10.1039/DT9850000275
DO - 10.1039/DT9850000275
M3 - Article
AN - SCOPUS:37049098210
SN - 1472-7773
SP - 275
EP - 278
JO - Journal of the Chemical Society, Dalton Transactions
JF - Journal of the Chemical Society, Dalton Transactions
IS - 2
ER -