Phosphorylated gelatin to enhance cell adhesion to titanium

Shin Hye Park; Liping Zhu; Seiichi Tada; Sei Obuse; Yasuhiro Yoshida; Mariko Nakamura; Tae Il Son; Satoshi Tsuneda; Yoshihiro Ito

doi:10.1002/pi.4647

Phosphorylated gelatin to enhance cell adhesion to titanium

Shin Hye Park, Liping Zhu, Seiichi Tada, Sei Obuse, Yasuhiro Yoshida, Mariko Nakamura, Tae Il Son, Satoshi Tsuneda, Yoshihiro Ito^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.

Original language	English
Pages (from-to)	1616-1619
Number of pages	4
Journal	Polymer International
Volume	63
Issue number	9
DOIs	https://doi.org/10.1002/pi.4647
Publication status	Published - 2014 Sept

Keywords

Cell adhesion
Gelatin
Phosphorylation
Titanium

ASJC Scopus subject areas

Polymers and Plastics
Organic Chemistry
Materials Chemistry

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10.1002/pi.4647

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title = "Phosphorylated gelatin to enhance cell adhesion to titanium",

abstract = "Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.",

keywords = "Cell adhesion, Gelatin, Phosphorylation, Titanium",

author = "Park, {Shin Hye} and Liping Zhu and Seiichi Tada and Sei Obuse and Yasuhiro Yoshida and Mariko Nakamura and Son, {Tae Il} and Satoshi Tsuneda and Yoshihiro Ito",

year = "2014",

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T1 - Phosphorylated gelatin to enhance cell adhesion to titanium

AU - Park, Shin Hye

AU - Zhu, Liping

AU - Tada, Seiichi

AU - Obuse, Sei

AU - Yoshida, Yasuhiro

AU - Nakamura, Mariko

AU - Son, Tae Il

AU - Tsuneda, Satoshi

AU - Ito, Yoshihiro

PY - 2014/9

Y1 - 2014/9

N2 - Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.

AB - Phosphorylated gelatin was prepared for surface modification of titanium to enhance cell attachment. The modified gelatin was synthesized by coupling gelatin with phosphonobutyric acid with water-soluble carbodiimide. Circular dichroism revealed no significant change in the gelatin as a result of phosphorylation. The binding behavior of phosphorylated gelatin on the titanium surface was observed by quartz crystal microbalance. The modified titanium surface was analyzed by measuring the water contact angle. Enhancement of the attachment of osteoblast cells MC-3T3L1 was observed on the phosphorylated-gelatin-modified titanium. Phosphorylation of gelatin was effective for preparation of a cell-adhesive titanium surface.

KW - Cell adhesion

KW - Gelatin

KW - Phosphorylation

KW - Titanium

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JO - Polymer International

JF - Polymer International

IS - 9

ER -

Phosphorylated gelatin to enhance cell adhesion to titanium

Abstract

Keywords

ASJC Scopus subject areas

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