@article{476643e63ceb441a89ffa7a4a66270d8,
title = "Physical Activity Protects the Pathological Alterations of Alzheimer{\textquoteright}s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways",
abstract = "Alzheimer{\textquoteright}s disease (AD) is a neurodegenerative disorder with typical amyloid beta (Aβ) aggregations. Elimination of the Aβ precursors via the kidneys makes the organ a potential factor in the systemic degeneration leading to AD. Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts neuroprotective effects in AD and plays a protective role in kidney pathologies. Increased physical activity is preventive of the formation of AD, but its detailed mechanism and possible connections with PACAP have not been clarified. In the kidneys of AD mice, the effects of physical activity were investigated by comparing wild-type and AD organs. Aβ plaque formation was reduced in AD kidneys after increased training (TAD). Mechanotransduction elevated PACAP receptor expression in TAD mice and normalized the protein kinase A (PKA)-mediated pathways. BMP4/BMPR1 elevation activated Smad1 expression and normalized collagen type IV in TAD animals. In conclusion, our data suggest that elevated physical activity can prevent the AD-induced pathological changes in the kidneys via, at least in part, the activation of PACAP–BMP signaling crosstalk.",
keywords = "Alzheimer{\textquoteright}s disease, BMP signaling, PACAP, collagen type IV, physical activity",
author = "Helga Per{\'e}nyi and Vince Szegeczki and Gabriella Horv{\'a}th and Barbara Hinnah and Andrea Tam{\'a}s and Zsolt Rad{\'a}k and D{\'o}ra {\'A}brah{\'a}m and R{\'o}za Z{\'a}k{\'a}ny and Dora Reglodi and Tam{\'a}s Juh{\'a}sz",
note = "Funding Information: We are grateful to Mrs. Krisztina B{\'i}r{\'o} for excellent technical assistance. Funding. NKFIK115874, PD109644, K119759, NKFIHFK129190, PTE AOK Research Grant, KA 2017-17, MTA-TKI 14016, GINOP-2.3.2-15-2016-00050 “PEPSYS,” New National Excellence Program of the Ministry of Human Capacities (UNKP-16-4-IV), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P{\'e}cs, EFOP-3.6.2-16-2017-00008 “The role of neuro-inflammation in neurodegeneration: from molecules to clinics” Center for Neuroscience of the University of P{\'e}cs, EFOP-3.6.3-VEKOP-16-2017-00009, University of Debrecen (OTKA Bridging Fund), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P{\'e}cs (Budapest, Hungary), NAP B KTIA NAP 13-2014-0022 (MTA-PTE NAP B Pain Research Group, identification number 888819), NAP 2017-1.2.1-NKP-2017-00002, and OTKA-NN 114458. The project was co-financed by the European Union and the European Social Fund. Bolyai Janos Research Scholarship (TJ and AT). Szodoray Lajos and Magyary Zolt{\'a}n Funds by the Hungarian Academy of Science and the European Union and the State of Hungary, co-financed by the European Social Funding. Fund in the framework of T{\'A}MOP 4.2.4 (TJ). VS was supported by the {\'U}NKP-19-3 “National Excellence Program” of the Ministry of Human Capacities. A/2-11-1-2012-0001 “National Excellence Program.” Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the FIKP II (2019) of the University of P{\'e}cs. National Excellence Program (126823) of Innovation and Technology Ministry, Hungary (ZR). Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Per{\'e}nyi, Szegeczki, Horv{\'a}th, Hinnah, Tam{\'a}s, Rad{\'a}k, {\'A}brah{\'a}m, Z{\'a}k{\'a}ny, Reglodi and Juh{\'a}sz.",
year = "2020",
month = aug,
day = "14",
doi = "10.3389/fncel.2020.00243",
language = "English",
volume = "14",
journal = "Frontiers in Cellular Neuroscience",
issn = "1662-5102",
publisher = "Frontiers Research Foundation",
}