TY - JOUR
T1 - Piceatannol is superior to resveratrol in promoting neural stem cell differentiation into astrocytes
AU - Arai, Daisuke
AU - Kataoka, Ryousuke
AU - Otsuka, Satoshi
AU - Kawamura, Midori
AU - Maruki-Uchida, Hiroko
AU - Sai, Masahiko
AU - Ito, Tatsuhiko
AU - Nakao, Yoichi
N1 - Publisher Copyright:
© 2016 The Royal Society of Chemistry.
PY - 2016/10
Y1 - 2016/10
N2 - Piceatannol (3,3′,4′,5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4′,5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol. At a concentration of 2.5 μM, piceatannol promoted astrocyte differentiation, while resveratrol had no effect at this concentration. Furthermore, we found that oral administration of piceatannol increased the number of astrocytes in the brains of adult mice, while resveratrol administration showed no effects. These results suggest that piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.
AB - Piceatannol (3,3′,4′,5-trans-tetrahydroxystilbene) is a polyphenolic compound abundant in the seeds of passion fruit (Passiflora edulis). Piceatannol is an analogue of resveratrol (3,4′,5-trans-trihydroxystilbene) and shares the structural motif and biological activities such as activation of SIRT1. Several studies have shown that piceatannol is more potent than resveratrol. In this study, we examined the effects of piceatannol on neural stem cell differentiation into astrocytes compared with those of resveratrol. At a concentration of 2.5 μM, piceatannol promoted astrocyte differentiation, while resveratrol had no effect at this concentration. Furthermore, we found that oral administration of piceatannol increased the number of astrocytes in the brains of adult mice, while resveratrol administration showed no effects. These results suggest that piceatannol has a superior effect to resveratrol in promoting astrocyte differentiation.
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U2 - 10.1039/c6fo00685j
DO - 10.1039/c6fo00685j
M3 - Article
C2 - 27713945
AN - SCOPUS:84991490640
SN - 2042-6496
VL - 7
SP - 4432
EP - 4441
JO - Food and Function
JF - Food and Function
IS - 10
ER -