TY - JOUR
T1 - Plasma cytokine changes in relation to exercise intensity and muscle damage
AU - Peake, Jonathan M.
AU - Suzuki, Katsuhiko
AU - Hordern, Matthew
AU - Wilson, Gary
AU - Nosaka, Kazunori
AU - Coombes, Jeff S.
N1 - Funding Information:
Acknowledgements This study was partly supported by a Waseda University Grant for Special Research Projects 2004A-288 and carried out in the Consolidated Research Institute for Advanced Science and Medical Care, Ministry of Education, Culture, Sports, Science and Technology, Japan. Jonathan Peake is a recipient of a postdoctoral fellowship from the Japanese Society for the Promotion of Science.
PY - 2005/12
Y1 - 2005/12
N2 - The purpose of this study was to compare the effects of exercise intensity and exercise-induced muscle damage on changes in anti-inflammatory cytokines and other inflammatory mediators. Nine well-trained male runners completed three different exercise trials on separate occasions: (1) level treadmill running at 60% V̇O2max (moderate-intensity trial) for 60 min; (2) level treadmill running at 85% for V̇O2max 60 min; (3) downhill treadmill running (-10% gradient) at 60% V̇O2max (downhill running trial) for 45 min. Blood was sampled before, immediately after and 1 h after exercise. Plasma was analyzed for interleukin-1 receptor antagonist (IL-1ra), IL-4, IL-5, IL-10, IL-12p40, IL-13, monocyte chemotactic protein-1 (MCP-1), prostaglandin E2, leukotriene B4 and heat shock protein 70 (HSP70). The plasma concentrations of IL-1ra, IL-12p40, MCP-1 and HSP70 increased significantly (P < 0.05) after all three trials. Plasma prostaglandin E2 concentration increased significantly after the downhill running and high-intensity trials, while plasma IL-10 concentration increased significantly only after the high-intensity trial. IL-4 and leukotriene B4 did not increase significantly after exercise. Plasma IL-1ra and IL-10 concentrations were significantly higher (P < 0.05) after the high-intensity trial than after both the moderate-intensity and downhill running trials. Therefore, following exercise up to 1 h duration, exercise intensity appears to have a greater effect on anti-inflammatory cytokine production than exercise-induced muscle damage.
AB - The purpose of this study was to compare the effects of exercise intensity and exercise-induced muscle damage on changes in anti-inflammatory cytokines and other inflammatory mediators. Nine well-trained male runners completed three different exercise trials on separate occasions: (1) level treadmill running at 60% V̇O2max (moderate-intensity trial) for 60 min; (2) level treadmill running at 85% for V̇O2max 60 min; (3) downhill treadmill running (-10% gradient) at 60% V̇O2max (downhill running trial) for 45 min. Blood was sampled before, immediately after and 1 h after exercise. Plasma was analyzed for interleukin-1 receptor antagonist (IL-1ra), IL-4, IL-5, IL-10, IL-12p40, IL-13, monocyte chemotactic protein-1 (MCP-1), prostaglandin E2, leukotriene B4 and heat shock protein 70 (HSP70). The plasma concentrations of IL-1ra, IL-12p40, MCP-1 and HSP70 increased significantly (P < 0.05) after all three trials. Plasma prostaglandin E2 concentration increased significantly after the downhill running and high-intensity trials, while plasma IL-10 concentration increased significantly only after the high-intensity trial. IL-4 and leukotriene B4 did not increase significantly after exercise. Plasma IL-1ra and IL-10 concentrations were significantly higher (P < 0.05) after the high-intensity trial than after both the moderate-intensity and downhill running trials. Therefore, following exercise up to 1 h duration, exercise intensity appears to have a greater effect on anti-inflammatory cytokine production than exercise-induced muscle damage.
KW - Anti-inflammatory cytokines
KW - Eccentric exercise
KW - Muscle damage
KW - Systemic stress
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U2 - 10.1007/s00421-005-0035-2
DO - 10.1007/s00421-005-0035-2
M3 - Article
C2 - 16151834
AN - SCOPUS:28844452841
SN - 1439-6319
VL - 95
SP - 514
EP - 521
JO - European Journal of Applied Physiology
JF - European Journal of Applied Physiology
IS - 5-6
ER -
