Point-to-Point Ultra-Remote Asymmetric Control with Flexible Linker

Tsuneomi Kawasaki, Yasuyuki Ishikawa, Yoshihiro Minato, Takashi Otsuka, Shigeru Yonekubo, Itaru Sato, Takanori Shibata, Arimasa Matsumoto, Kenso Soai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


An ultra-remote intramolecular (point-to-point) asymmetric control through 38 bonds (1,39-asymmetric induction) has been achieved by using the principle of direct supramolecular orientation of catalytic and reactive moieties in asymmetric autocatalysis. We found the highly stereoselective diisopropylzinc addition reaction using designed molecules possessing pyrimidine sites at each terminal of a conformationally flexible simple methylene chain.

Original languageEnglish
Pages (from-to)282-285
Number of pages4
JournalChemistry - A European Journal
Issue number2
Publication statusPublished - 2017 Jan 5


  • 5-pyrimidyl alkanol
  • asymmetric amplification
  • intramolecular stereocontrol
  • remote asymmetric induction
  • stereoselective reaction

ASJC Scopus subject areas

  • Catalysis
  • Organic Chemistry


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