Polygenic risk for hypertriglyceridemia is attenuated in Japanese men with high fitness levels

Kumpei Tanisawa, Tomoko Ito, Xiaomin Sun, Zhen Bo Cao, Shizuo Sakamoto, Masashi Tanaka, Mitsuru Higuchi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


High cardiorespiratory fitness (CRF) is associated with a reduced risk for dyslipidemia; however, blood lipid levels are also affected by individual genetic variations. We performed a cross-sectional study to determine whether CRF modifies polygenic risk for dyslipidemia. Serum levels of triglycerides (TG), LDL cholesterol (LDL-C), and HDL cholesterol (HDL-C) were measured in 170 Japanese men (age 20-79 yr). CRF was assessed by measuring maximal oxygen uptake (VO2max), and subjects were divided into low-fitness and high-fitness groups according to the reference VO2max value for health promotion in Japan. We analyzed 19 single nucleotide polymorphisms (SNPs) associated with TG, LDL-C, or HDL-C levels. Based on these SNPs, we calculated three genetic risk scores (GRSs: TG-GRS, LDL-GRS, and HDL-GRS), and subjects were divided into low, middle, and high groups according to the tertile for each GRS. Serum TG levels of low-fitness individuals were higher in the high and middle TG-GRS groups than in the low TG-GRS group (P < 0.01 and P < 0.05, respectively), whereas no differences were detected in the TG levels of high-fitness individuals among the TG-GRS groups. In contrast, the high LDL-GRS group had higher LDL-C levels than did the low LDL-GRS group, and HDL-C levels were lower in the high HDL-GRS group than in the low HDL-GRS group regardless of the fitness level (P < 0.05). These results suggest that high CRF attenuates polygenic risk for hypertriglyceridemia; however, high CRF may not modify the polygenic risk associated with high LDL-C and low HDL-C levels in Japanese men.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalPhysiological Genomics
Issue number6
Publication statusPublished - 2014 Mar 15


  • Blood lipid
  • Cardiorespiratory fitness
  • Hypertriglyceridemia
  • Polygenic risk

ASJC Scopus subject areas

  • Physiology
  • Genetics


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