Potential improvement in rehabilitation quality of 2019 novel coronavirus by isometric training system; is there “muscle-lung cross-talk”?

Hadi Nobari*, Mohamad Fashi*, Arezoo Eskandari, Jorge Pérez-Gómez, Katsuhiko Suzuki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


The novel Coronavirus Disease 2019 (COVID-19) crisis is now present in more than 200 countries. It started in December 2019 and has, so far, led to more than 149, 470,968 cases, 3,152,121 deaths, and 127,133,013 survivors recovered by 28 April 2021. COVID-19 has a high morbidity, and mortality of 2%, on average, whereas most people are treated after a period of time. Some people who recover from COVID-19 are left with 20 to 30% decreased lung function. In this context, exercise focused on skeletal muscle with minimal lung involvement could potentially play an important role. Regular exercise protects against diseases associated with chronic low-grade systemic inflam-mation. This long-term effect of exercise may be ascribed to the anti-inflammatory response elicited by an acute bout of exercise, which is partly mediated by muscle-derived myokines. The isometric training system seems to have this feature, because this system is involved with the skeletal muscle as the target tissue. However, no studies have examined the effect of exercise on the treatment and recovery of COVID-19, and, more importantly, “muscle–lung cross-talk” as a mechanism for COVID-19 treatment. It is suggested that this theoretical construct be examined by researchers.

Original languageEnglish
Article number6304
JournalInternational journal of environmental research and public health
Issue number12
Publication statusPublished - 2021 Jun 2


  • Anti-inflammatory treatment
  • COVID-19
  • Chronic diseases
  • Cytokines
  • Exercise
  • Fibroblast growth factor 21
  • Immune response
  • Myokines
  • Oxidative stress

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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