Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga; Keitaro Sou; Shinji Takeoka; Eishun Tsuchida

Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Shunsuke Inenaga^*, Keitaro Sou, Shinji Takeoka, Eishun Tsuchida

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

Original language	English
Pages	4866
Number of pages	1
Publication status	Published - 2006
Event	55th Society of Polymer Science Japan Symposium on Macromolecules - Toyama, Japan Duration: 2006 Sept 20 → 2006 Sept 22

Other

Other	55th Society of Polymer Science Japan Symposium on Macromolecules
Country/Territory	Japan
City	Toyama
Period	06/9/20 → 06/9/22

Keywords

Anionio lipid
Curcumin
Drug delivery
Emulsion
Lipophilic drug
Pharmacokinetics

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug",

abstract = "The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.",

keywords = "Anionio lipid, Curcumin, Drug delivery, Emulsion, Lipophilic drug, Pharmacokinetics",

author = "Shunsuke Inenaga and Keitaro Sou and Shinji Takeoka and Eishun Tsuchida",

year = "2006",

language = "English",

pages = "4866",

note = "55th Society of Polymer Science Japan Symposium on Macromolecules ; Conference date: 20-09-2006 Through 22-09-2006",

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TY - CONF

T1 - Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

AU - Inenaga, Shunsuke

AU - Sou, Keitaro

AU - Takeoka, Shinji

AU - Tsuchida, Eishun

PY - 2006

Y1 - 2006

N2 - The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

AB - The purpose of this study is efficient delivery of lipophilic drug such as curcumin using pharmacokinetics of nanoparticles with anionic lipid (L-Glutamic acid-N-(3-carboxyl-1-oxopropyl)-1,5-dihexadecyl ester (DHSG)). The o/w emulsions with (DMPC/DHSG/PEG-DSPE: 10/1/0.06 molar ratio) were prepared. We incorporated curcumin, into the emulsions and evaluated them. Furthermore, the organ distribution of the resulting emulsions was investigated to evaluate the pharmacokinetics in rats.

KW - Anionio lipid

KW - Curcumin

KW - Drug delivery

KW - Emulsion

KW - Lipophilic drug

KW - Pharmacokinetics

UR - http://www.scopus.com/inward/record.url?scp=33846127856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33846127856&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33846127856

SP - 4866

T2 - 55th Society of Polymer Science Japan Symposium on Macromolecules

Y2 - 20 September 2006 through 22 September 2006

ER -

Preparation and evaluation of o/w emulsions with an anionic lipid, containing lipophilic drug

Abstract

Other

Keywords

ASJC Scopus subject areas

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