Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai; Ryouta Araki; Kazue Hiraka; Shoichiro Asayama; Shoji Nagaoka; Tomomi Hatsugai; Akihiko Ogata; Kenichi Oyaizu; Makoto Yuasa; Hiroyoshi Kawakami

Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Miho Tamai^*, Ryouta Araki, Kazue Hiraka, Shoichiro Asayama, Shoji Nagaoka, Tomomi Hatsugai, Akihiko Ogata, Kenichi Oyaizu, Makoto Yuasa, Hiroyoshi Kawakami

^*Corresponding author for this work

Research output: Contribution to conference › Paper › peer-review

Abstract

We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O₂^- · to H₂O₂ and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H ₂O₂ and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

Original language	English
Number of pages	1
Publication status	Published - 2005 Dec 1
Externally published	Yes
Event	54th SPSJ Annual Meeting 2005 - Yokohama, Japan Duration: 2005 May 25 → 2005 May 27

Conference

Conference	54th SPSJ Annual Meeting 2005
Country/Territory	Japan
City	Yokohama
Period	05/5/25 → 05/5/27

Keywords

Anticancer drug
Drug delivery system
Liposome
Metalloporphyrin

ASJC Scopus subject areas

Engineering(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Preparation of nanocarriers containing SOD mimics and their anticancer mechanism",

abstract = "We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.",

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author = "Miho Tamai and Ryouta Araki and Kazue Hiraka and Shoichiro Asayama and Shoji Nagaoka and Tomomi Hatsugai and Akihiko Ogata and Kenichi Oyaizu and Makoto Yuasa and Hiroyoshi Kawakami",

year = "2005",

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day = "1",

language = "English",

note = "54th SPSJ Annual Meeting 2005 ; Conference date: 25-05-2005 Through 27-05-2005",

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TY - CONF

T1 - Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

AU - Tamai, Miho

AU - Araki, Ryouta

AU - Hiraka, Kazue

AU - Asayama, Shoichiro

AU - Nagaoka, Shoji

AU - Hatsugai, Tomomi

AU - Ogata, Akihiko

AU - Oyaizu, Kenichi

AU - Yuasa, Makoto

AU - Kawakami, Hiroyoshi

PY - 2005/12/1

Y1 - 2005/12/1

N2 - We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

AB - We have reported the anticancers effect by metalloporphyrins as SOD mimics on the cancer cells. Metalloporphyrins as SOD mimics convert intracellular O2- · to H2O2 and it reacts on iron porphyrins to form OH · by Fenton reaction. Finally H 2O2 and OH- generated by the metalloporphyrin are expected to cause cell death. We have prepared novel liposomes containing metallporphyrins showing SOD activity. The liposomes were composed of DMPC and their size was less than 100nm. The liposomes showed a significant cytotoxicty for cancer cells when compared with cisplatin and metalloporphyrins.

KW - Anticancer drug

KW - Drug delivery system

KW - Liposome

KW - Metalloporphyrin

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UR - http://www.scopus.com/inward/citedby.url?scp=33645633922&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33645633922

T2 - 54th SPSJ Annual Meeting 2005

Y2 - 25 May 2005 through 27 May 2005

ER -

Preparation of nanocarriers containing SOD mimics and their anticancer mechanism

Abstract

Conference

Keywords

ASJC Scopus subject areas

UN SDGs

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