Preparation of pH-responsive liposomes with aminolipids

Yosuke Obata*, Shinji Takeoka

*Corresponding author for this work

Research output: Contribution to conferencePaperpeer-review


The development of gene delivery technologies is required using novel nonviral lipids. In this paper, we synthesized hydrolysis of the lipids from amino acids. Our synthesized hydrolysis of the lipids have glutamic acid or lysine skeleton as a hydrophobic part and have glutamic acid as a hydrophilic part. We studied the release of fluorescent from liposome induced by the hydrolysis of the amino lipids. We reported the synthetic methods of the lipids and evaluated the characteristics of the lipids. Furthermore, we prepared liposomes having the amino lipids as a part of membrane components and evaluated their release of liposomes.

Original languageEnglish
Number of pages2
Publication statusPublished - 2005 Dec 1
Event54th SPSJ Symposium on Macromolecules - Yamagata, Japan
Duration: 2005 Sept 202005 Sept 22


Other54th SPSJ Symposium on Macromolecules


  • Amino lipid
  • Drug delivery
  • Liposome

ASJC Scopus subject areas

  • Engineering(all)


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