Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes

Yosuke Obata; Daisuke Suzuki; Shinji Takeoka

Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes

Yosuke Obata^*, Daisuke Suzuki, Shinji Takeoka

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We have developed amino lipids as pH-sensitive components of liposomes because of their low costs and low toxicities. Liposomes are required not only to control the behavior in circulation but also to control the release behavior of encapsulated drugs. We designed zwitter-ionic lipid from glutamic acid as a pH-sensitive lipid. The pH-sensitive lipid changes the head-group charge according to pH. We prepared pH-sensitive liposomes composed of the synthesized pH-sensitive amino lipid and studied the release behavior of albumin from the liposome under low pH and revealed the dynamics in fibroblast cells (CCD-32SK).

Original language	English
Number of pages	1
Publication status	Published - 2006 Oct 19
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Amino lipids
Controlled release
Drug delivery system
Liposome
PH-sensitive

ASJC Scopus subject areas

Engineering(all)

Cite this

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title = "Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes",

abstract = "We have developed amino lipids as pH-sensitive components of liposomes because of their low costs and low toxicities. Liposomes are required not only to control the behavior in circulation but also to control the release behavior of encapsulated drugs. We designed zwitter-ionic lipid from glutamic acid as a pH-sensitive lipid. The pH-sensitive lipid changes the head-group charge according to pH. We prepared pH-sensitive liposomes composed of the synthesized pH-sensitive amino lipid and studied the release behavior of albumin from the liposome under low pH and revealed the dynamics in fibroblast cells (CCD-32SK).",

keywords = "Amino lipids, Controlled release, Drug delivery system, Liposome, PH-sensitive",

author = "Yosuke Obata and Daisuke Suzuki and Shinji Takeoka",

year = "2006",

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day = "19",

language = "English",

note = "55th SPSJ Annual Meeting ; Conference date: 24-05-2006 Through 26-05-2006",

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T1 - Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes

AU - Obata, Yosuke

AU - Suzuki, Daisuke

AU - Takeoka, Shinji

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We have developed amino lipids as pH-sensitive components of liposomes because of their low costs and low toxicities. Liposomes are required not only to control the behavior in circulation but also to control the release behavior of encapsulated drugs. We designed zwitter-ionic lipid from glutamic acid as a pH-sensitive lipid. The pH-sensitive lipid changes the head-group charge according to pH. We prepared pH-sensitive liposomes composed of the synthesized pH-sensitive amino lipid and studied the release behavior of albumin from the liposome under low pH and revealed the dynamics in fibroblast cells (CCD-32SK).

AB - We have developed amino lipids as pH-sensitive components of liposomes because of their low costs and low toxicities. Liposomes are required not only to control the behavior in circulation but also to control the release behavior of encapsulated drugs. We designed zwitter-ionic lipid from glutamic acid as a pH-sensitive lipid. The pH-sensitive lipid changes the head-group charge according to pH. We prepared pH-sensitive liposomes composed of the synthesized pH-sensitive amino lipid and studied the release behavior of albumin from the liposome under low pH and revealed the dynamics in fibroblast cells (CCD-32SK).

KW - Amino lipids

KW - Controlled release

KW - Drug delivery system

KW - Liposome

KW - PH-sensitive

UR - http://www.scopus.com/inward/record.url?scp=33749846830&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749846830&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:33749846830

T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Preparation of pH-sensitive liposomes composed of amino lipids and the release behavior of macromolecules from the liposomes

Abstract

Conference

Keywords

ASJC Scopus subject areas

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