TY - JOUR
T1 - Preparation of pH-sensitive liposomes retaining SOD mimic and their anticancer effect
AU - Hiraka, Kazue
AU - Kanehisa, Mayuko
AU - Tamai, Miho
AU - Asayama, Shoichiro
AU - Nagaoka, Shoji
AU - Oyaizu, Kenichi
AU - Yuasa, Makoto
AU - Kawakami, Hiroyoshi
N1 - Funding Information:
This work was partially supported by a Grant-in Aid (No. 18650132) from Japan Society for the Promotion of Science.
PY - 2008/11/15
Y1 - 2008/11/15
N2 - We prepared an anticancer drug based on a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe-porphyrin, 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine, dimethylditetradecylammonium bromide, sodium oleate, and Tween-80. The Fe-porphyrin was released from the liposome at low pH, and the cytotoxicity for cancer cells by the liposome depended on the acidic environments of the endosomes in the cells. Furthermore, although the liposome exhibited an excellent anticancer effect on a gastric cancer cell line, the SOD activity of Fe-porphyrin was shown to have a significant influence on the cytotoxicity toward cancer cells. These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape.
AB - We prepared an anticancer drug based on a pH-sensitive liposome retaining Fe-porphyrin as an SOD mimic. The liposomes contained cationic/anionic lipid combinations and were composed of Fe-porphyrin, 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine, dimethylditetradecylammonium bromide, sodium oleate, and Tween-80. The Fe-porphyrin was released from the liposome at low pH, and the cytotoxicity for cancer cells by the liposome depended on the acidic environments of the endosomes in the cells. Furthermore, although the liposome exhibited an excellent anticancer effect on a gastric cancer cell line, the SOD activity of Fe-porphyrin was shown to have a significant influence on the cytotoxicity toward cancer cells. These findings suggest that the pH-sensitive liposome retaining the Fe-porphyrin as an SOD mimic promises to be a novel anticancer drug for endosomal escape.
KW - Anticancer
KW - Endosomal escape
KW - Fe-porphyrin
KW - SOD mimic
KW - pH-sensitive liposome
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U2 - 10.1016/j.colsurfb.2008.07.014
DO - 10.1016/j.colsurfb.2008.07.014
M3 - Article
C2 - 18775654
AN - SCOPUS:53149133871
SN - 0927-7765
VL - 67
SP - 54
EP - 58
JO - Colloids and Surfaces B: Biointerfaces
JF - Colloids and Surfaces B: Biointerfaces
IS - 1
ER -
