Preparation of wettability modulated thermoresponsive surfaces by ATRP and elution control of biomolecules

Naokazu Idota*, Akihiko Kikuchi, Jun Kobayashi, Kiyotaka Sakai, Teruo Okano

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution


Temperature-dependent aqueous wettability of poly(N-isopropylacrylamide) (PIPAAm)-grafted surfaces was regulated by thickness of graft polymer layer and architecture of polymer chains utilizing surface-initiated atom transfer radical polymerization (ATRP). Hydrophilic property on the PIPAAm-grafted surfaces depends on polymer layer thickness at low temperature range. More hydrophobic surface properties were observed for poly (n-butyl methacrylate) (PBMA)-b-PIPAAm-grafted surfaces above PIPAAm's transition temperature. Applying surface-initiated ATRP of IPAAm to inner surfaces of microcapillaries, the retention times of steroids were controlled solely by temperature changes. Testosterone showed stronger interaction with more hydrophobic PBMA-e-PIPAAm-grafted surfaces above PIPAAm's LCST, and baseline separation of steroids was successfully achieved within 10min by only temperature alterations.

Original languageEnglish
Title of host publicationPolymer Preprints, Japan
Number of pages2
Publication statusPublished - 2005
Event54th SPSJ Symposium on Macromolecules - Yamagata
Duration: 2005 Sept 202005 Sept 22


Other54th SPSJ Symposium on Macromolecules


  • Atom transfer radical polymerization
  • Block copolymer
  • Glass capillary
  • Hydrophobic interaction
  • Thermoresponsive polymer

ASJC Scopus subject areas

  • General Engineering


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