Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Shumei Murakami; Rinus G. Verdonschot; Naoya Kakimoto; Iori Sumida; Masateru Fujiwara; Kazuhiko Ogawa; Souhei Furukawa

doi:10.1371/journal.pone.0154226

Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Shumei Murakami, Rinus G. Verdonschot, Naoya Kakimoto, Iori Sumida, Masateru Fujiwara, Kazuhiko Ogawa, Souhei Furukawa

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Purpose: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. Methods: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. Results: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. Conclusions: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

Original language	English
Article number	e0154226
Journal	PLoS One
Volume	11
Issue number	4
DOIs	https://doi.org/10.1371/journal.pone.0154226
Publication status	Published - 2016 Apr 1
Externally published	Yes

ASJC Scopus subject areas

Agricultural and Biological Sciences(all)
Biochemistry, Genetics and Molecular Biology(all)
Medicine(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0154226

Cite this

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abstract = "Purpose: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. Methods: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. Results: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. Conclusions: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.",

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AU - Murakami, Shumei

AU - Verdonschot, Rinus G.

AU - Kakimoto, Naoya

AU - Sumida, Iori

AU - Fujiwara, Masateru

AU - Ogawa, Kazuhiko

AU - Furukawa, Souhei

PY - 2016/4/1

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N2 - Purpose: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. Methods: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. Results: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. Conclusions: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

AB - Purpose: To point out the advantages and drawbacks of high-dose rate brachytherapy in the treatment of mobile tongue cancer and indicate the clinical importance of modular lead-lined spacers when applying this technique to patients. Methods: First, all basic steps to construct the modular spacer are shown. Second, we simulate and evaluate the dose rate reduction for a wide range of spacer configurations. Results: With increasing distance to the source absorbed doses dropped considerably. Significantly more shielding was obtained when lead was added to the spacer and this effect was most pronounced on shorter (i.e. more clinically relevant) distances to the source. Conclusions: The modular spacer represents an important addition to the planning and treatment stages of mobile tongue cancer using HDR-ISBT.

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Preventing complications from high-dose rate brachytherapy when treating mobile tongue cancer via the application of a modular lead-lined spacer

Abstract

ASJC Scopus subject areas

UN SDGs

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