Abstract
An oral administration of χ-tocotrienol (χ-T3) or χ-tocopherol (χ-Toc) to male rats caused an increase of the concentration of 2,7,8-trimethyl-2-(β-carboxyethyl)-6-hydroxy chroman (LLU-α, χ-CEHC), a natriuretic compound, in plasma with a T(m)(a)(x) of 9 h. The configuration at C-2 of LLU-α produced from χ-T3 or χ-Toc was assigned as S-form by an HPLC equipped with a chiral column. These data indicated that LLU-α was produced not only from χ-Toc but also χ-T3, without racemization at C-2 in rats.
| Original language | English |
|---|---|
| Pages (from-to) | 1395-1397 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 23 |
| Issue number | 11 |
| Publication status | Published - 2000 |
| Externally published | Yes |
Keywords
- χ-tocopherol
- χ-tocotrienol
- HPLC
- LLU-α(χ-CEHC)
- Rat plasma
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)