Progress in the control system of the undulation pump total artificial heart

Itsuro Saito*, Tsuneo Chinzei, Yusuke Abe, Mitsuhiko Ishimaru, Shuichi Mochizuki, Toshiya Ono, Takashi Isoyama, Kiyotaka Iwasaki, Akimasa Kouno, Atsushi Baba, Toshinaga Ozeki, Koki Takiura, Takahiro Tohyama, Hidemoto Nakagawa, Kou Imachi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


The undulation pump total artificial heart (UPTAH) is a small implantable total artificial heart. As the UPTAH generates outflow and inflow at the same time, control of the UPTAH is very difficult. Therefore suitable control methods specifically for the UPTAH should be established. Various motor control, left-right flow balance control, and physiological control methods were examined and tried for the UPTAH control in this study. The control system is divided into seven categories. It has a hierarchical structure and all control modes work at the same time. The UPTAH with the newly developed control method has been implanted into the chest cavities of 48 goats. Until now, six goats survived for more than one month, including 63 days in the longest case. The good condition of the UPTAH implanted animal could be maintained with the newly developed control scheme, consisting of the 1/R control and several other additional controls.

Original languageEnglish
Pages (from-to)27-33
Number of pages7
JournalArtificial Organs
Issue number1
Publication statusPublished - 2003


  • 1/R control
  • Control system
  • Total artificial heart
  • Undulation pump

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomaterials
  • Biomedical Engineering


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