Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie; Yousuke Okamura; Shinji Takeoka; Makoto Handa; Yasuo Ikeda

Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Toshinori Fujie^*, Yousuke Okamura, Shinji Takeoka, Makoto Handa, Yasuo Ikeda

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to conference › Paper › peer-review

Abstract

We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

Original language	English
Number of pages	1
Publication status	Published - 2006 Oct 19
Event	55th SPSJ Annual Meeting - Nagoya, Japan Duration: 2006 May 24 → 2006 May 26

Conference

Conference	55th SPSJ Annual Meeting
Country/Territory	Japan
City	Nagoya
Period	06/5/24 → 06/5/26

Keywords

Blood circulation clearance
Fibrinogen γ chain dodecapeptide (H12)
Hemostatic effect
Platelet substitutes
Polyethyleneglycol

ASJC Scopus subject areas

Engineering(all)

Cite this

Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes. / Fujie, Toshinori; Okamura, Yousuke; Takeoka, Shinji et al.
2006. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.

Research output: Contribution to conference › Paper › peer-review

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abstract = "We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.",

keywords = "Blood circulation clearance, Fibrinogen γ chain dodecapeptide (H12), Hemostatic effect, Platelet substitutes, Polyethyleneglycol",

author = "Toshinori Fujie and Yousuke Okamura and Shinji Takeoka and Makoto Handa and Yasuo Ikeda",

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T1 - Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

AU - Fujie, Toshinori

AU - Okamura, Yousuke

AU - Takeoka, Shinji

AU - Handa, Makoto

AU - Ikeda, Yasuo

PY - 2006/10/19

Y1 - 2006/10/19

N2 - We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

AB - We conjugated dodecapeptide (H12), which was a part of the amino acid sequence of fibrinogen, to the terminal of polyethyleneglycol (PEG) chains of the PEG-modified polymerized albumin particles(polyAlb), and confirmed that they showed a significant hemostatic effect even 3hrs after injection(40mg/kg) in thrombocytopenic rats.

KW - Blood circulation clearance

KW - Fibrinogen γ chain dodecapeptide (H12)

KW - Hemostatic effect

KW - Platelet substitutes

KW - Polyethyleneglycol

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M3 - Paper

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T2 - 55th SPSJ Annual Meeting

Y2 - 24 May 2006 through 26 May 2006

ER -

Prolongation effects of hemostatic ability of poly(ethyleneglycol)-modified polymerized albumin particles carrying fibrinogen-γ chain dodecapeptide (H12) as platelet substitutes

Abstract

Conference

Keywords

ASJC Scopus subject areas

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