Prolonged exercise causes an increase in endothelin-1 production in the heart in rats

Seiji Maeda, Takashi Miyauchi*, Satoshi Sakai, Tsutomu Kobayashi, Motoyuki Iemitsu, Katsutoshi Goto, Yasuro Sugishita, Mitsuo Matsuda

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)


Cardiac myocytes produce endothelin-1 (ET-1). ET-1 has potent positive inotropic and chronotropic effects. We investigated whether production of ET- 1 in the heart is altered by prolonged exercise in rats. Rats ran on a treadmill for 45 min. Immediately after this exercise the heart and lungs were quickly removed. Control rats remained at rest during this 45-min period. Expression of preproET-1 mRNA in the heart was markedly higher in the exercised than in the control rats. The peptide level of ET-1 in the heart was also markedly higher in the exercised rats. Expression of endothelin type A- and type B-receptor mRNA and endothelin-converting enzyme mRNA in the heart did not differ between the groups. The peptide level of ET-1 and the preproET-1 mRNA level in the lungs of the exercised rats did not differ from those in the control rats. The present results show that production of ET-1 is markedly increased tissue specifically in the heart by exercise without appreciable changes in endothelin-converting enzyme and endothelin receptor expression. The present study suggests that myocardial ET-1 may participate in modulation of cardiac function during exercise.

Original languageEnglish
Pages (from-to)H2105-H2112
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Issue number6 44-6
Publication statusPublished - 1998 Dec
Externally publishedYes


  • Endothelin type A receptor
  • Endothelin type B receptor
  • Endothelin- converting enzyme
  • Myocardial endothelin-1
  • Positive inotropy
  • Treadmill running

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)


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