Psg18 is specifically expressed in follicle-associated epithelium

Kazuya Kawano, Masashi Ebisawa, Koji Hase, Shinji Fukuda, Atsushi Hijikata, Sayaka Kawano, Yasuhiro Date, Satoshi Tsuneda, Kikuji Itoh, Hiroshi Ohno*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


Pregnancy-specific glycoproteins (Psgs) secreted by the placenta regulate the immune system to ensure the survival of the fetal allograft by inducing IL-10, an anti-inflammatory cytokine. However, it is unknown whether Psgs are involved in more general aspects of immune response other than maternal immunity. Here, we report that Psg18 is highly expressed in the follicle-associated epithelium (FAE) overlaying Peyer's patches (PPs). Bioinformatics analysis with Reference Database for Immune Cells (RefDIC) as well as RT-PCR data demonstrated that Psg18 is exclusively expressed in FAE in adult mice, in contrast to other Psg family members that are either not expressed or only slightly expressed in FAE. Psg18 expression was observed in FAE of germ-free-conditioned mice, and was slightly upregulated after bacterial inoculation. In situ hybridization analysis revealed that Psg18 is widely expressed throughout FAE. Furthermore, Psg18 protein is deposited on the extracellular matrix in the subepithelial dome beneath FAE, where antigen-presenting cells accumulate. These results suggest that Psg18 is an FAE-specific marker protein that could promote interplay between FAE and immune cells in mucosa-associated lymphoid tissues.

Original languageEnglish
Pages (from-to)115-126
Number of pages12
JournalCell Structure and Function
Issue number2
Publication statusPublished - 2007


  • FAE
  • Microarray
  • Mucosal immunity
  • Peyer's patch
  • Pregnancy-specific glycoprotein 18

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology


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