Pulmonary effects of sodium fluoride aerosol on rats

X. Q. Chen*, K. Machida, K. Isizaki, N. Nisio, M. Ando

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)


    Five-week-old male Fischer rats were exposed 3 hr per day for either 5 or 10 days to three concentrations of sodium fluoride aerosol (1.11, 3.33, and 10.3 mg F/m3). A significant increase in lung weight was observed at the highest concentration. The activity of lactate dehydrogenase (LDH) and total protein concentration in bronchoalveolar lavage (BAL) fluid were also significantly higher in rats exposed to 3.33 and 10.3 mg F/m3. Neutrophil phagocytic activity in the blood was stimulated by 10-day exposure, and a significant increase in bactericidal activity and superoxide production was observed by exposure to 3.33 mg F/m3 but not to 10.3 mg F/m3.

    Original languageEnglish
    Pages (from-to)159-167
    Number of pages9
    Issue number4
    Publication statusPublished - 2000


    • Aerosol fluoride
    • Airborne fluoride
    • Bronchoalveolar lavage
    • Lactate dehydrogenase
    • Neutrophil stimulation
    • Phagocytic activity
    • Pulmonary effects
    • Rat lungs

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)
    • Health, Toxicology and Mutagenesis
    • Public Health, Environmental and Occupational Health
    • Toxicology


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