Recent advances in reproductive neuroendocrinology: A role for RFamide peptides in seasonal reproduction?

Timothy J. Greives, Lance J. Kriegsfeld, George E. Bentley, Kazuyoshi Tsutsui, Gregory E. Demas

    Research output: Contribution to journalArticlepeer-review

    37 Citations (Scopus)


    Most temperate-zone species use photoperiod to coordinate breeding and ensure that offspring are born during favourable conditions. Although photoperiodic influences on the reproductive axis have been well characterized, the precise mechanisms by which photoperiodic information and other seasonal cues are integrated to regulate reproductive function remain less well specified. Two recently discovered neuropeptides, kisspeptin and gonadotropin-inhibitory hormone, have pronounced opposing influences on reproductive function. This paper will review recent evidence for a role of these peptides in seasonal reproduction and propose a theoretical framework by which these novel regulatory peptides may serve to regulate seasonal breeding. Understanding the mechanisms regulating appropriate changes in reproductive status will serve to advance a wide range of life science disciplines.

    Original languageEnglish
    Pages (from-to)1943-1951
    Number of pages9
    JournalProceedings of the Royal Society B: Biological Sciences
    Issue number1646
    Publication statusPublished - 2008 Sept 7


    • Gonadotropin-inhibitory hormone
    • Kisspeptin
    • Metastin
    • RFamide
    • RFamide-related peptide
    • Seasonal reproduction

    ASJC Scopus subject areas

    • Agricultural and Biological Sciences(all)
    • Agricultural and Biological Sciences (miscellaneous)


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