Recent Advances of Biphenylene: Synthesis, Reactions and Uses

Hideaki Takano, Takeharu Ito, Kyalo Stephen Kanyiva, Takanori Shibata*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

22 Citations (Scopus)


Biphenylene is an antiaromatic compound that has a strained butadiene skeleton that joins two benzene rings. Various methods for synthesizing the biphenylene core have been developed. In addition, the reactivity of biphenylene has attracted much attention because C–C bonds of biphenylene can be cleaved by various organometallic species. Furthermore, the biphenylene motif not only acts as a spacer in a variety of functional molecules, but also serves as a backbone for catalysts and ligands. This minireview summarizes how to construct the biphenylene structure, how to react biphenylene, and how to use the biphenylene skeleton in functional materials.

Original languageEnglish
Pages (from-to)2871-2883
Number of pages13
JournalEuropean Journal of Organic Chemistry
Issue number18
Publication statusPublished - 2019 May 15


  • Biphenylene
  • C–C activation
  • Hydrocarbons
  • Metallacycles
  • Strained molecules

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry


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